As of late 2014, nearly 4,000 properties in the state of Ohio were listed on the National Register of Historic Places, and one of them is the Cleveland Fed's own. Opened in 1923, the Federal Reserve Bank of Cleveland's headquarters is a Cleveland landmark built in imposing Italian Renaissance Revival Style. Its lobby walls are covered with golden marble from Italy, its ceiling, impossibly tall with deeply recessed, hand-painted panels. Each of the lobby's 12 windows bears the seal of one of the 12 cities in which Federal Reserve Banks operate. The building's old-world elegance extends 8 floors up, too, to the Cleveland Fed's executive floor, which is paneled in American black walnut with grandiose pillars and hand-stenciled design on the walls. The seals of each of the states of the Fourth Federal Reserve District (Ohio, Pennsylvania, West Virginia, and Kentucky) are featured prominently on 4 panels in the floor's Reception Room.

The building is said to be haunted by the ghost of a woman named Matilda. She is reportedly dressed as a flapper, and she killed herself in 1929 when the stock market crashed and she lost everything. She apparently stalks employees throughout the bank. Perhaps she was trying to warn them.