The plantation traces its roots back to Jean Baptiste LeComte II, who received French and Spanish land grants in the mid-18th century. This began the plantation's recorded history, although the first structures were not built until the 19th century, and the plantation was not operating until 1830. Ambrose LeComte, son of Jean Baptiste, married Julia Buard. They began a tradition of community and cultivation on a vast piece of property. Their two daughters, Laura and Ursula Atala, married two sons from the Hertzog family: Bernard Theophile Henry and Matthew Hertzog, respectively. Atala and Matthew Hertzog took over the plantation shortly after their marriage in 1852, thus linking the Hertzog name to Magnolia.

Magnolia Plantation is exceptional because of the surviving farming technology, such as the cotton picker tractors and two cotton gins (both steam- and animal-powered). It has 21 buildings that contribute to the significance of the site, an unusually high number for surviving plantations. Among these are the eight quarters, rare brick cabins used by workers who lived and worked on the plantation for 100 years after the American Civil War.

The plantation was also exceptional for its influence in the community and the Cane River area. For 100 years after the American Civil War, "the Hertzogs," as the place was familiarly known, served as the center of a community of Creoles of color and blacks who lived and worked on the plantation as tenant farmers and laborers. By the mid-20th century, changes in agriculture led people to urban jobs

Magnolia Plantation is a former plantation in Natchitoches Parish, Louisiana. The site was declared a National Historic Landmark in 2001. Included in the Cane River Creole National Historical Park, Magnolia Plantation is also a destination on the Louisiana African American Heritage Trail.